Exercise Heart Rates in Patients with Hypertrophic Cardiomyopathy

HONG-CHANG LUO; VERONICA LEA DIMAANO; JACKELYN M. KEMBRO; ALEX HILSER; DAVID HURTADO-DE-MENDOZA; IRAKLIS POZIOS; MIGUEL SANTAULARIA TOMAS; HULYA YALCIN; KETTY DOLORES-CERNA; WILFREDO MORMONTOY; MIGUEL A. AON; DUKE CAMERON; DAVID A. BLUEMKE; KERRY J. STEWART; STUART D. RUSSELL; JORGE GONZALES CORDOVA; THEODORE P. ABRAHAM ; M. ROSELLE ABRAHAM

AMERICAN JOURNAL OF CARDIOLOGY

EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC

Año: 2015 vol. 115 p. 1144 - 1150

0002-9149

The exercise heart rate (HR) profile and its relationship to cardiac function and arrhythmias was investigated in patients with hypertrophic cardiomyopathy (HC). Chronotropic response (CR) and heart rate recovery (HRR) were computed during and after treadmill exercise testing in 273 HC patients and 95 age-matched healthy controls. HC patients had higher prevalence of chronotropic incompetence and lower HRR1-5min compared to controls. Exercise capacity, diastolic function (assessed by E/e´ and left atrial volume index were associated with HRR1min and CR in HC. Septal myectomy was associated with reduction in chronotropic incompetence, but did not affect HRR1min. In conclusion, impaired CR and HRR1min are associated with advanced disease and do not appear to be independent clinical markers indicating high risk status in HC. Improving CR by titrating doses of negative chronotropic agents, myectomy and atrial pacing may be useful to increase exercise capacity in HC patients.