Neuroprotective effect of Ilex paraguariensis intake on brain myelin of lung adenocarcinoma-bearing male balb/c mice

MIRANDA AR; REPOSSI G; CITTADINI MC; MAZZUDULI GM; ALBRECHT C; SORIA EA

Córdoba

Congreso; VII Congreso Internacional de Ciencia y Tecnología de Alimentos; 2018

Ministerio de Ciencia y Tecnología de la Prov. de Córdoba

Ilex paraguariensis (IP) is widely consumed as tea with high nutritional value. This plant contains several bioactive phenolic compounds, which are antioxidant and antiinflammatory. On the other hand, lung adenocarcinoma (LAC) deleteriously involves neoplastic progression, inflammatory paraneoplastic syndromes, and death. Given that brain is a frequent target of this illness, our objective was to determine the neuroprotective effect of IP consumption in LAC-bearing mice. They were orally treated with 50 mg of IP extract/Kg/day (IP50) for 3 weeks. Results (phenolic compounds, lipid peroxides, interleukin 6 -IL-6-, tumor necrosis factor alpha -TNFα-, and luxol-stained myelination) were compared with respect to untreated controls (C) by the T test. IP50 significantly lowed brain IL-6 (2858.12±57.81 pg/g vs. 3801.30±27.34 pg/g), whereas other variables differed in a less extent. C brains showed demyelination (low luxol-staining contrast between gray and white matters), with IP50 increasing myelination (p