Maternal triclosan consumption predisposes to metabolic syndrome in Wistar rat offspring

JUAN PABLO LOPEZ; MARIA BELEN RABAGLINO; NESTOR GARCIA; MARIA JOSE MOREIRA-ESPINOZA; DANTE BELTRAMO

Aspen/Snowmass

Simposio; Perinatal Biology Symposium; 2016

Triclosan (TCS) is a synthetic antibacterial compound utilized in cosmetic industry and considered safe for its use in humans. The objective of this study was to evaluate the effect of maternal oral TCS intake during gestation and lactation on the metabolic status of the adult offspring.Pregnant Wistar rats were fed ad-libitum with ground food + TCS (1 mg/kg) from day 14 of gestation to day 20 of lactation (n=3) or ground food (n=3). Litter size was reduced to 4 males and 4 females after born. Thus, 12 males and 12 females born from the TCS exposed rats (TCS, n=24) or not (Control, n=24) composed the experimental groups. Monthly body weight, food intake at 2 and 5 months and plasmatic levels of cholesterol, glucose and triglycerides at 8 months of age were measured. The effect of group on each variable was analyzed by t-test for each gender and age. Body weight was significantly heavier for males in the TCS group at 4 months (515.6 ± 38.3 grs versus 451.25 ± 51.1 grs, p