INTRAGESTATIONAL ROLE OF GHRELIN ON OFFSPRING´S POSNATAL DEVELOPMENT AND REPRODUCTIVE FUNCTION

DI GIORGIO N; CARLINI VP; LUQUE EM; FIGUEROA SI; MARTINI AC; TORRES PJ; DIEZ M; VINCENTI LM

BS AS

Congreso; SAIC; 2016

Sociedad Argentina de Investigación Clínica

It has been proposed that ghrelin (Ghr) exerts an important role in pregnancy success and offspring´s postnatal development. Therefore, the objective of this study was to evaluate the effects of intragestational exogenous Ghr administration or endogenous Ghr inhibition (using an antagonist) on mice posnatal development.Dams were injected (s.c.) through pregnancy with: Ghr (4 nmol/animal/day), an antagonist (Ant: (D-Lys3)GHRP-6; 6 nmol/animal/day) or vehicle (C: isotonic solution). Their litters were evaluated for posnatal growth, neurobiologic development and sexual maturation and, at adulthood, for reproductive success. Results were analyzed using ANOVA.Neither daily intake nor dam´s weight was modified by the treatments. Litter growth or physical/neurobiological maturation were not altered either. Male offspring under intragestational treatment with Ant showed a faster sexual development (testicular descent day 19: Ant=64±5.9% vs Ghr=50.1±6.9% and C=44.9±7.9%, n=7-13 litters/treatment; p