Obesity, ghrelin and reproductive success in women under assisted reproductive technologies

NOVILLO JM; HERNÁNDEZ M; ESTOFÁN D; ESTOFÁN P; MOLINA RI; DEMATEIS A; ESTOFÁN G; MARTINI AC

Tucumán

Congreso; Tercera Reunión de las Sociedades de Biología Argentinas; 2015

Female obesity has been associated with subfertility and, in some cases, with modifications in serum ghrelin (Ghr) concentrations. A recent clinical study reported a negative correlation between Ghr and embryo viability or cleavage. In this study, we aimed to investigate in women with indication of ICSI (intracitoplasmatic sperm injection), the possible association between Ghr, body mass index (BMI), other reproductive hormones and treatment success.We evaluated 75 women (from July 2014 to March 2015) that assisted to our fertility clinic (CIGOR). They were younger than 40, with no polichistic ovarian syndrome and their partners did not show evidences for severe male factor infertility. Thirty patients were normal, 29 were overweight (OW) and 16 were obese (OB). Patients? age or years of sterility did not vary between groups, and were 34.5±0.4 and 3.6±0.3 respectively. Serum Ghr was significantly higher in OB than OW (2559.7±297.9 vs 1695.3±182.4 pg/ml, p