FAMILY HISTORY OF PREMATURE CARDIOVASCULAR EVENTS AND TOTAL PLAQUE AREA

HERNAN A. PEREZ; NESTOR HORACIO GARCIA; PAUL ATKINS; SONIA E MUNOZ; J. DAVID SPENCE; LUIS J. ARMANDO

Amsterdam

Simposio; 7th International Symposium on Atherosclerosis; 2015

International Atherosclerosis Society

Background and Objectives: Although a family history of premature cardiovascular events (FHPCVE) has been considered a putative risk factor for decades, it has not been incorporated in cardiovascular risk evaluation in daily clinical practice along with other established risk factors such as hyperlipidemia, hypertension, and smoking. The objective of this study was to investigatewhether FHPCVE is associated with a higher atherosclerotic burden, measured as carotid total plaque area (TPA), in a population with no traditional risk factors and no personal history of CVE. Methods: Using the Blossom DMO primary prevention database (Argentina) consisting of 4351 patients, 34 individuals with FHPCVE were identified after applying exclusion for traditional risk factors and previous CVE. The definition of the Framingham study (family history of CAD