Blood phenolics levels as biomarkers of its concentration and bioactivity on central nervous system of mice exposed to plant infusions

CITTADINI MC; ALBRETCH C; CANALIS AM; VALENTICH MA; REPOSI G; SORIA E

Valencia

Congreso; Oxigen Club of California World Congress, ?Oxidants and antioxidants in biology?.; 2015

The Oxigen Club of California

Blood phenolics levels as biomarkers of its concentration and bioactivity on central nervous system of mice exposed to plant infusions Cittadini María Cecilia1,2,3; Albrecht Claudia1,2,3; Canalis Alejandra Mariel1,2; Valentich Mirta2; Repossi Gastón2; Soria Elio Andrés2 1 Escuela de Nutrición, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba. 2Instituto de Investigaciones en Ciencias de la Salud- INICSA-CONICET. Facultad de Ciencias Médicas, Universidad Nacional de Córdoba. 3Instituto Nacional del Cáncer. Ministerio de Salud de la Nación.Argentina. Natural phenolics are phytochemicals present in plant foods, which have antioxidant properties. After intake, they are transported by blood proteins to different organs, such as metabolic organs and the central nervous system (CNS) given their capacity to cross blood-brain barrier. Thus, it might be possible to correlatetheir blood concentration with those found in CNS tissues and with their redox state. The aim of our work was to assess the value of blood phenolic dosage as biomarker of organic phenolics and oxidation in BALB/C mice after 0-30 days of intake of different infusive extracts from L. grisebachii (LG), I. paraguariensis (IP)andA. quebracho-blanco (AQB) (100 mg/Kg/d). The following parameters were analyzedhydroperoxides (AHP), lipoperoxides (LHP) and phenolicsin CNS (thelencephalon, diencephalon, mesencephalon, encephalic stem, and cerebellum), liver, kidney and blood. It was found a positive correlation between phenolics in blood and in brain (pr=0.81; p