INICSA   23916
INSTITUTO DE INVESTIGACIONES EN CIENCIAS DE LA SALUD
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
The activation of Bronchiolar Clara cells and Alveolar Macrophage innate immunity prevents allergic inflammation of airways
Autor/es:
GARCIA LN, LEIMGRUBER C, URIBE ECHEVARRÍA EM,QUINTAR AA, MALDONADO CA
Lugar:
Los Cocos, Córdoba
Reunión:
Congreso; LXI Reunión Científica Anual de la Sociedad Argentina de Inmunología; 2013
Institución organizadora:
Sociedad Argentina de Inmunología
Resumen:
A possible reason for the crescent asthma rate is the lack of microbial stimulating signals of the modern lifestyle. It has been suggested that a response triggered by environmental endotoxins through innate immune (ii) receptors like Toll- like receptors (TLR), may counterbalance the T helper (Th)-2 response of atopic asthma. Bronchiolar Clara Cells (CC) and Alveolar Macrophages (AM) are key players in lung homeostasis by means of several defense mechanisms which are disturbed during asthma development. Therefore, our aim was to evaluate if the local stimulus with E. Coli Lipopolysaccharide (LPS) can prevent allergic airway inflammation (aai) and if CC and AM ii mechanisms are involved. For this purpose, an Ovalbumin (OVA) asthma model in female Balb/c (n=12/group) was performed (OVA group) while a second group received intranasal LPS prior to OVA scheme (LPSOVA). By AB-PAS in lung tissue, LPSOVA showed a reduction of mucous metaplasia compared to OVA (p