CONICET | Buscador de Institutos y Recursos Humanos

Acute ghrelin administration reverses the memory impairment induced by bilateral olfactory bulbectomy in mice. Paula Rodriguezb; Valeria Paola Carlinia, Maria Belén Porettia; Marta Fiol de Cuneoa, and Susana R. de Bariogliob. aCátedra de Fisiología, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Argentina. bDpto. de Farmacología Facultad de Ciencias Químicas, Universidad Nacional de Córdoba. (IFEC-CONICET), Argentina This study aims to examine the effects of gherlin (Ghr) a hormone synthesized predominantly by gastrointestinal endocrine cells and released during periods of negative energy balance, on memory impairment induced by bilateral olfactory bulbectomy, a well-established animal model of depression. In a previous work we demonstrated that Ghr 0.3 nmol/µl, produced antidepressant-like effect and reversed OB-induced depressive-like behavior. Adult male Albino?s Swiss mice were divided in two groups: without bulbectomy (Sham) and bulbectomized (OB). Both groups were cannulated intracerebroventricularly and seven days after, the memory performance was evaluated using the object recognition test. The animals were infused with saline or Ghr 0.3 nmol/µl immediately after training (n=10 animals/group). The OB animals infused with saline (OB-S) showed a decrease in the time of novel object exploration in relation to Sham animals indicating memory impairment (F=15.62, df=1, p≤ 0.05). When Ghr was administrated to OB, the memory retention increased in relation to OB-S mice, reaching a performance similar to Sham animals (p≤ 0.05). In conclusion, these results provide clear evidence that the acute Ghr administration reverse the memory impairment induced by bilateral olfactory bulbectomy in mice.