Do Exposure to Arsenic, Occupation and Diet have Synergistic Effects on Prostate Cancer Risk?

NICLIS, C; DÍAZ, MP; NICLIS, C; DÍAZ, MP; ROMÁN, MD; LANTIERI, MJ; ROMÁN, MD; LANTIERI, MJ; ABALLAY, LR; MUÑOZ, SE; ABALLAY, LR; MUÑOZ, SE

ASIAN PACIFIC JOURNAL OF CANCER PREVENTION

ASIAN PACIFIC ORGANIZATION CANCER PREVENTION

Lugar: Tehran; Año: 2018 vol. 19 p. 1495 - 1501

1513-7368

Background: Diverse environmental exposures, as well as dietary and lifestyle factors, are associated with prostatecancer (PC) etiology; however little is known about joint interactive influences. The aim of this study was to analyseeffects of diet combined with arsenic in drinking water and agricultural occupation on PC risk. Methods: A case-controlstudy was conducted in Córdoba, Argentina (period 2008-2015) including 147 cases of PC and 300 controls. All subjectswere interviewed about food consumption, socio-demographic and lifestyle characteristics. A sample of drinking waterwas taken to determine arsenic concentrations. Adherence scores to the Traditional Dietary Pattern were estimated, basedon a principal component factor analysis. A two-level logistic regression model was fitted in order to assess effects ofthe Traditional Pattern, occupation and arsenic exposure on the occurrence of PC (outcome). Family history of PC wasconsidered as a clustering variable. Results: PC risk was greatest in subjects with high adherence to the Traditional Pattern(OR 2.18; 95%IC 1.097?4.344). Subjects exposed to arsenic in drinking water above 0.01mg/l who simultaneouslyperformed agricultural activities showed a markedly elevated PC risk (OR 5.07; 95%IC 2.074-12.404). Variance ofthe random effect of family history of PC was significant. conclusion: Diet, arsenic and occupation in agriculture exertsignificant effects on PC risk. Further efforts are necessary to analyse risk factors integrally, in order to achieve a betterunderstanding of the complex causal network for PC in this multiple-exposure population.