INICSA 23916
INSTITUTO DE INVESTIGACIONES EN CIENCIAS DE LA SALUD
Unidad Ejecutora - UE
artículos
Título:
Role of intragestational ghrelin on postnatal development and reproductive programming in mice
Autor/es:
PONZIO MF; FIGUEROA S; MARTINI AC; TORRES PJ; CANTARELLI V; LUQUE EM (DEBE SER CONSIDERADA COMO PRIMERA AUTORA CONJUNTA); VINCENTI LM; DIEZ M; CARLINI VP
Revista:
REPRODUCTION
Editorial:
BIOSCIENTIFICA LTD
Referencias:
Lugar: Bristol; Año: 2018 vol. 156 p. 331 - 341
ISSN:
1470-1626
Resumen:
The purpose of this study was to evaluate the intragestational role of ghrelin in offspring development and reproductive programming in a mouse model of ghrelin imbalance during pregnancy. Female mice were injected with ghrelin (supraphysiological levels; 4 nmol/animal/day), antagonist (endogenous ghrelin inhibition with (D-Lys3)GHRP-6, 6 nmol/animal/day) or vehicle (control=normal ghrelin levels) for the entire pregnancy. Parameters evaluated in litters were growth, physical, neurobiological and sexual development and, at adulthood, reproductive function. Litter size and initial weight did not vary between treatments. Male pups from dams treated with ghrelin showed higher body weight increase until adulthood (31.7±0.8 vs control=29.7±0.7, n=11-14 litters/treatment; p
