Increased inflammatory potential of diet is associated with increased odds of prostate cancer in Argentinian men

DIAZ, MARÍA DEL PILAR; BECARIA COQUET, JULIA ; ROMÁN, MARÍA D.; SHIVAPPA, NITIN; HÉBERT, JAMES R.; NICLIS, CAMILA

CANCER CAUSES & CONTROL

SPRINGER

Lugar: Berlin; Año: 2018

0957-5243

PurposeVarious aspects of diet, including specific food items and nutrients, have been shown to modulate inflammation and have been implicated in the etiology of prostate cancer (PrCA). No study examining the role of diet-associated inflammation in PrCA has been conducted in Latin America.MethodWe examined the association between the Dietary Inflammatory Index (DII®) and PrCA in a population-based case?control study in Córdoba, Argentina. A total of 153 incident cases of PrCA and 309 controls frequency matched on sex, age (± 5 years), and place of residence were recruited from 2008 to 2015. The DII was developed to determine the inflammatory potential of individuals? diets and was computed from a validated food frequency questionnaire using nutrient data from diet only. Multi-level logistic regression models were fit to evaluate the association between DII scores and PrCA, adjusting for age, body mass index, energy intake, and occupational exposure as first-level covariates and family history of prostate cancer as the second-level variable. Odds ratios were estimated in all subject and stratified by BMI (