INICSA   23916
INSTITUTO DE INVESTIGACIONES EN CIENCIAS DE LA SALUD
Unidad Ejecutora - UE
artículos
Título:
Differences between preschoolers with asthma and allergies in urban and rural environments
Autor/es:
MARFORTT, DANIEL A.; CUESTAS, EDUARDO; JOSVIACK, DARIO; AG?ERO, LUIS; LOZANO, ALEJANDRO; CASTRO-RODRIGUEZ, JOSE A.
Revista:
JOURNAL OF ASTHMA
Editorial:
TAYLOR & FRANCIS INC
Referencias:
Lugar: Londres; Año: 2017 p. 1 - 1
ISSN:
0277-0903
Resumen:
Objective: The influence of living in a rural or urban environment on asthma and allergic diseases inschool-children provide conflicting results; moreover none of these studies included exclusivelypreschoolers. The aim of the present study was to evaluate if recurrent wheezing preschoolers from ruralor urban areas differ in asthma, allergic diseases, and atopy. Methods: A cross-sectional-study in Rafaela,Argentina, on 143 preschoolers with recurrent wheezing from rural and urban settings was performed(2010-2012). Diagnosis of asthma (by positive asthma predictive index [API]), allergic diseases (rhinitis,dermatitis), and atopy (by skin prick test [SPT], peripheral blood eosinophils, and serum total IgE) wereevaluated. Results: Preschoolers from rural settings had significantly higher prevalence of vaginaldelivery, longer breastfeeding, earlier onset of wheezing, more parental smoking, siblings, shared abedroom, and more exposure to chemicals used in plant fumigation or farm animals, and unpasteurizedmilk consumption, in comparison to preschoolers living in urban setting. In contrast, preschoolers fromurban areas had significantly higher prevalence of parental history of allergy, positive skin prick test, andpositive API. After multivariate analysis adjusting for covariates, maternal smoking (OR = 3.44), andpositive SPT (OR = 5.57) significantly increase the risk of asthma diagnosis (positive API); in contrast,living in rural setting (OR = 0.04), and having more siblings (OR = 0.51) decrease their risk. Conclusions:Recurrent wheezing preschoolers from rural areas had a significant inverse odds of being diagnosed withasthma (type-2 inflammation) when compared to those from urban areas. Exposure to farm animals andconsumption of unpasteurized milk might have a role.
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