INICSA   23916
INSTITUTO DE INVESTIGACIONES EN CIENCIAS DE LA SALUD
Unidad Ejecutora - UE
artículos
Título:
Tissue-specific bioconcentration and biotransformation of cypermethrin and chlorpyrifos in a native fish (Jenynsia multidentata) exposed to these insecticides singly and in mixtures
Autor/es:
ROCÍO INÉS BONANSEA; DANIEL ALBERTO WUNDERLIN; BERTRAND LIDWINA; MARINO, DAMIAN; AME MARIA VALERIA
Revista:
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
Editorial:
SETAC PRESS
Referencias:
Lugar: Michigan; Año: 2016
ISSN:
0730-7268
Resumen:
The aim of the present study was to evaluate the accumulation of cypermethrin (CYP) and chlorpyrifos (CPF) when the fish Jenynsia multidentata was exposed to these pesticides singly and in technical and commercial mixtures. Adult female fishes were exposed over 96 h to 0.04 μg/L of CYP; 0.4 μg/L of CPF; 0.04 μg/L CYP + 0.4 μg/L CPF in a technical mixture; and 0.04 μg/L CYP + 0.4 μg/L CPF in a mixture of commercial products. Fish exposed to CYP accumulated this compound only in muscle, probably due to low biotransformation capacity of this organ and to the induction of cytochrome P4501A1 (CYP1A1) expression in the liver. The accumulation of CPF occurred in fish exposed to the insecticide (intestine>liver>gills) even when these fishes had higher Gluthatione S-transferase activity in gills and P-glycoprotein (P-gp) expression in liver, compared with the control.Fish exposed to the technical mixture showed CYP accumulation (liver>intestine>gills) with higher levels than measured in fish after singly CYP exposure. Higher expression levels of CYP1A1 in liver were also observed compared with the control. Fish exposed to the commercial mixture accumulated both insecticides (CYP: intestine>gills and CPF: liver>intestine>gills>muscle). In the organs where accumulation occurred, biotransformation enzymes were inhibited. Consequently, the commercial formulation exposure provoked the highest accumulation of CYP and CPF in J.multidentata, possibly associated with the biotransformation system inhibition. This article is protected by copyright. All rights reserved
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