IDEA   23902
INSTITUTO DE DIVERSIDAD Y ECOLOGIA ANIMAL
Unidad Ejecutora - UE
artículos
Título:
Population genetic structure and demographic history of Streptococcus mutans (Bacteria: Streptococcaceae)
Autor/es:
GONZÁLEZ ITTIG RE; JIMENEZ MG; CARLETTO KÖRBER FPM; CORNEJO LS; VERA NS
Revista:
BIOLOGICAL JOURNAL OF THE LINNEAN SOCIETY
Editorial:
WILEY-BLACKWELL PUBLISHING, INC
Referencias:
Lugar: Londres; Año: 2017 vol. 120 p. 705 - 716
ISSN:
0024-4066
Resumen:
Population genetic studies can contribute to current knowledge about the epidemiology of pathogens such asStreptococcus mutans, which is one of the most widely distributed bacteria in the world to be associated with3 human dental caries. In the present study, we investigated whether the population genetic structure of thespecies is clonal or recombinant, and we also evaluated the current levels of gene flow, admixed ancestry, and thehypothesis of an expansion of the bacteria within the last 10 000 years. Strains of S. mutans from C ordoba(Argentina) were obtained, with sequences of the genes aroE, gltA, gyrA, and lepC genes being aligned with thoseof strains from Japan, Thailand, and Finland. Most of our statistical analyses performed on the DNA matrix of193 strains supported the existence of recombination at the intergene level. We also estimated the number ofgenetic clusters via Bayesian analyses, with three genetic clusters being detected in the four countries atdifferent frequencies, as well as the number of strains with pure or admixed ancestry varying among countries.Argentina revealed 50% admixed strains, whereas these types of strains were present in only 8?19% of the otherthree countries analyzed. This result could be associated with the important human migration waves thatArgentina has experienced, which may have mixed strains of S. mutans of different geographical origins. Thedemographic history was obtained using Extended Bayesian Skyline Plot anslysis, which showed importantgrowth in the effective population size approximately 5000 years ago, coincident with the beginning of thedispersion of agriculture and a change to a diet rich in carbohydrates.