IDEA   23902
INSTITUTO DE DIVERSIDAD Y ECOLOGIA ANIMAL
Unidad Ejecutora - UE
artículos
Título:
Bioaccumulation and bioconcentration of carbamazepine and other pharmaceuticals in fish under field and controlled laboratory experiments. Evidences of carbamazepine metabolization by fish
Autor/es:
D.A. WUNDERLIN; S. RODRIGUEZ-MOZAZ; HUERTA B; D. BARCELÓ; M. E. VALDES; M. A. BISTONI
Revista:
SCIENCE OF THE TOTAL ENVIRONMENT
Editorial:
ELSEVIER SCIENCE BV
Referencias:
Lugar: Amsterdam; Año: 2016 vol. 557 p. 58 - 58
ISSN:
0048-9697
Resumen:
There is a growing interest in evaluating the presence of pharmaceutical residues and their metabolites in aquaticbiota. In this study, twenty pharmaceuticals, including carbamazepine (CBZ) and two metabolites, were analyzedin homogenates of two fish species (Gambusia affinis and Jenynsia multidentata) captured in polluted areas of theSuquía River (Córdoba, Argentina). The twenty target pharmaceuticals were found in G. affinis, while only fifteenwere detected in J. multidentata. We observed a noticeable difference in the accumulation pattern of both fishspecies, suggesting different pathways for the bioaccumulation of polar pharmaceuticals in each fish.In order to investigate uptake and tissue distribution of pharmaceuticals, a detailed study was performed undercontrolled laboratory conditions in J. multidentata, exposed to CBZ. CBZ and two of its metabolites (carbamazepine-10,11-epoxide? CBZ-EP and 2-hydroxycarbamazepine ? 2-OH-CBZ) were monitored in five organs of fishunder laboratory exposure. To our knowledge, this is the first report on the presence of CBZ and its metabolite2-OH-CBZ in gills, intestine, liver, brain and muscle of fish, while the metabolite carbamazepine-10,11-epoxide(CBZ-EP) was detected in gills and muscle. A ratio CBZ-EP/CBZ close to 0.1 suggests that gills and muscle ofJ. multidentata could metabolize CBZ through the CBZ-EP pathway