INVESTIGADORES
GARCIA Mariana Gabriela
artículos
Título:
Altered hyaluronan biosynthesis and cancer progression: an immunological perspective.
Autor/es:
ALANIZ L; GARCÍA MG; RIZZO M; PICCIONI F; MAZZOLINI G
Revista:
MINI-REVIEWS IN MEDICINAL CHEMISTRY
Editorial:
BENTHAM SCIENCE PUBL LTD
Referencias:
Año: 2009 vol. 9 p. 1538 - 1546
ISSN:
1389-5575
Resumen:
Hyaluronan is a glycosaminglycan present in practically all tissues as an important component of the extracellular matrix. In spite of its apparent simple chemical structure, hyaluronan is a molecule with multiple and complex physiogical and pathological functions. Hyaluronan is able to regulate a variety of biological processes such as cellular growth, migration, differentiation and inflammation, not only in normal but also in cancer tissues. Besides, increasing evidence suggests hyaluronan as a potent modulator of immune responses which supports a potential role of this molecule in cancer immunotherapy.
