IIMYC   23581
INSTITUTO DE INVESTIGACIONES MARINAS Y COSTERAS
Unidad Ejecutora - UE
artículos
Título:
Activity of Palythoa caribaeorum venom on voltage-gated ion channels in mammalian superior cervical ganglion neurons
Autor/es:
FERNANDO LAZCANO-PÉREZ; DAVID E. GARCÍA; HÉCTOR CASTRO; RICARDO GONZÁLEZ MUÑOZ; ISABEL ARENAS; ROBERTO ARREGUÍN-ESPINOSA
Revista:
Toxins
Editorial:
MDPI AG
Referencias:
Lugar: Basel; Año: 2016 vol. 8
Resumen:
The Zoanthids are an order of cnidarians whose venoms and toxins have been poorly studied. Palythoa caribaeorum is a zoanthid commonly found around the Mexican coastline. In this study, we tested the activity of P. caribaeorum venom on voltage-gated sodium channel (NaV1.7), voltage-gated calcium channel (CaV2.2), the A-type transient outward (IA) and delayed rectifier (IDR) currents of KV channels of the superior cervical ganglion (SCG) neurons of the rat.These results showed that the venom reversibly delays the inactivation process of voltage-gated sodium channels and inhibits voltage-gated calcium and potassium channels in this mammalian model. The compounds responsible for these effects seem to be low molecular weight peptides. Together, these results provide evidence for the potential use of zoanthids as a novel source of cnidarian toxins active on voltage-gated ion channels.