IMAS 23417
INSTITUTO DE INVESTIGACIONES MATEMATICAS "LUIS A. SANTALO"
Unidad Ejecutora - UE
artículos
Título:
Asymmetries in kinesin-2 and cytoplasmic dynein contributions to melanosome transport.
Autor/es:
MARIA CECILIA DE ROSSI, MARIA EMILIA DE ROSSI; MARIELA SUED; DANIELA RODRIGUEZ; LUCIANA BRUNO, VALERIA LEVI
Revista:
FEBS LETTERS
Editorial:
ELSEVIER SCIENCE BV
Referencias:
Lugar: Amsterdam; Año: 2015 vol. 589 p. 2763 - 2768
ISSN:
0014-5793
Resumen:
The mechanisms involved in bidirectional transport along microtubules remain largely unknown.We explored the collective action of kinesin-2 and dynein motors during transport of melanosomesinXenopus laevis melanophores. These motors are attached to organelles through accessory pro-teins establishing a complex molecular linker. We determined both the stiffness of this linker andthe organelles speed and observed that these parameters depended on the organelle size and cargodirection. Our results suggest that melanosome transport is driven by two dissimilar teams: whereasdynein motors compete with kinesin-2 affecting the properties of plus-end directed organelles,kinesin-2 does not seem to play a similar role during minus-end transport
