IFISUR   23398
INSTITUTO DE FISICA DEL SUR
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Analysis of the five-fold symmetry axis of icosahedral virus capsids
Autor/es:
JUAN FRANCISCO VISO; FERNANDO ZAMARREÑO; MARÍA JULIA AMUNDARAIN; DIEGO MARCELO GUÉRIN AGUILAR; MARCELO DANIEL COSTABEL
Lugar:
Caxambu
Reunión:
Congreso; XXIX reunion anual de la federación de sociedad de biología experimental; 2014
Institución organizadora:
Universidad de Sao Pablo
Resumen:
Viral capsids play a crucial role in the process of viral infection, nevertheless, very little is known of this process. Better understanding of the structural properties, which are related with the virus functionality, it is important to comprehend this mechanism. In this work we study the structure of different viral capsids and compare their tridimensional configuration as well as their aminoacids composition and properties. In particular we focus our study in Triatoma Virus and compare it with other viruses from the same viral family, dicistroviridae, and viruses with similar structure. The reason for studing TrV is because it infects several species of triatomine insects, which are the vectors for human trypanosiomiasis, commonly known as Chagas Disease. Because of this TrV is proposed as a biological control against this kind of insects. For this reason it is important to better understand its structure. To this end, we use Molecular Dynamics to do computational simulations of the different systems. These simulations are done with the program Gromacs. Since the number of particles that form the viral capsids is very large, we focus our attention to the pentameric subunit form around the five-fold symmetry axis. Finally, we carry out a comparison analysis of all the structures.