. Total, android and gynoid mass in normal weight and overweight women. The influence of menopause.

MASTAGLIA SR; SOLIS F; BAGUR A; MAUTALEN C; OLIVERI B

Toronto ( Canada)

Congreso; 32nd Annual Meeting of The American Society for Bone and Mineral Research (ASBMR); 2010

The American Society for Bone and Mineral Research (ASBMR)

Obesity is a world public health problem. It is an independent risk factor for cardiovascular disease and increases morbimortality. Dual X-ray absorptiometry is a valid method to estimate body composition. Objective: 1-to study a population of women aged 20 to 69 years to obtain normal values for total (TF), android (AF), and gynoid (GF) fat, and android/gynoid coefficient (A/G); 2- to evaluate whether menopause (MP) affects TF, AF, and GF distribution similarly in normal weight and overweight women. Material and Methods: Seventy and seven women, average age (X ±DS) 49±14  years (range 20-70 years), were studied. Those receiving hormonal contraceptives, hormone replacement therapy, or medication affecting adipose tissue, or participating in weight loss programs were excluded. Total (TF) and regional (gynoid (GF)/android (AF)) fat were determined using a GE Lunar- Prodigy machine (software Encore version 8.1). Statistical analysis was used to compare pre vs. postmenopause, dividing the population according to BMI. Results: 33 pre-MP (BMI 21±2 Kg/m2) and 44 post-MP (BMI 22±2 Kg/m2) women were normal weight (control group); 13 pre-MP (BMI 26±1 Kg/m2) and 19  post-MP (BMI 27±1Kg/m2) women were overweight. Results are shown in Table 1 (X±DS). During menopause, normal weight women showed changes in TF distribution (18.3±5 vs. 19.6±3 kg, ns) at the expense of AF (1.3±0.5 vs. 1.5±0.5kg, p<0,04) and increase in A/G index (0.7 vs. 0.8, p<0.01). Results showed no significant changes in GF. During menopause, overweight women no exhibited significant changes (GT: 27.6±3 vs. 27.0±4 kg; ns; GA: 2.2±0.5 vs. 2.3±0.5kg; ns, GG: 5.5±0.8kg vs. 5.0±0.8; ns; and  A/G:0.9vs.0.9;ns). Conclusion: 1- Fat redistribution during menopause in normal weight women involves greater android fat deposits. 2- Android and gynoid fat deposits increase equally in overweight women. 3- Peripheral conversion to estrogens may contribute to lessening changes in fat compartments in overweight women. Table 1: Results of the studied population (X±DS)         Normal Women   Characteristics  TF AF GF A/G   n Age  BMI Kg % Kg % Kg %   Pre-MP 33 34±9 21±2 18.3±5 31.9±7 1,3±0,5 33.3±9 4.2±0.9 43.4±5 0.7 Post-MP 44 59±9 22±2 19.6±3 34.1±4 1,5±0,5 37.2±8 4.0±0.7 44.1±4 0.8 p   0.00 ns ns ns 0.04 ns ns ns 0.01