INVESTIGADORES
PONCE Nora Marta Andrea
artículos
Título:
Fucoidans from the phaeophyta Scytosiphon lomentaria: Chemical analysis and antiviral activity of the galactofucan component
Autor/es:
PONCE, NORA M.A.; FLORES, MARÍA L.; PUJOL, CARLOS A.; BECERRA, MÓNICA B.; NAVARRO, DIEGO A.; CÓRDOBA, OSVALDO; DAMONTE, ELSA B.; STORTZ, CARLOS A.
Revista:
CARBOHYDRATE RESEARCH
Editorial:
ELSEVIER SCI LTD
Referencias:
Año: 2019 vol. 478 p. 18 - 24
ISSN:
0008-6215
Resumen:
The brown seaweed Scytosiphon lomentaria produces moderate amounts of fucoidans. By cetrimide fractionation,typical heavily sulfated galactofucans are obtained, with no major signs of chemical heterogeneity, together withfractions with higher proportions of xylose, mannose and uronic acids. Anyway, fucose is the most importantmonosaccharide in most of the subfractions of the subsequent extracts. The fucan moieties appear to be mostly as3-linked α-L-fucopyranosyl units, with several patterns of sulfate and branching. Galactose is mostly 6-linked,whereas mannose appears to be 2-linked, and xylose appears mostly as terminal stubs. Small amounts of 2-Oacetylatedfucose units appear. A high and selective antiviral activity against HSV-1 and HSV-2 was determinedfor the galactofucan fractions whereas the uronofucoidans were inactive.