CARACTERIZATION IN VITRO OF CEFTAZIDIME AND VANCOMYCIN EYEDROPS RECONSTITUTED IN MEDIUM DIFFERENT

SILVINA VILARRUBI; BESSONE CAROLINA; PALMA S.; ALLEMANDI D A.; DANIELA QUINTEROS

ROSARIO

Congreso; Ricifa 2016. Reunión internacional de ciencias farmaceuticas; 2016

RICIFA

Purpouse: Therapeutic failures to treat Pseudomonas aeruginosa and Staphylococcus aureus infections of the eye with conventional regimens, as well as the emergence of resistant strains of these bacteria, have necessitated the use of fortified antibiotic eyedrops in subjects who do not respond to conventional treatment modalities, as is often the case in longterm care. The increasing need for such treatments has led to the recent appearance in the literature of a number of studies examining the in vitro characteristics of fortified antibiotic eyedrops. We aimed to study the in vitro caracterization of ceftazidime and vancomycin eyedrops. Methods: Solutions of ceftazidime 30 mg / mL and vancomycin 30 mg / mL. Were prepared by reconstituting with water, buffer pH 6 and pH 7 respectively and stored at 24 ° C without exposure to light. Also the solutions were prepared with one or two drugs. Changes in the pH values, concentration of the drugs and physical characteristics of the solutions were recorded for the seven days. Results: The ceftazidime solutions increased of the pH in the solutions and coincides with the appearance of visual and olfactory signs of degradation. In the solution of vancomicy in water and pH: 6 the pHs drecreased and pH:7 vancomicin solution precpitates. When this solutions were mixed the precipited was observed in all solution. the ceftazidime solution was not precipited at all pH but vancomicin solution were precipited at pH:7.Conclusion: With the results obtained, we prepared the eyes reconstituted drops that could be used as an alternative for treating ophthalmic infections resistant.