INVESTIGADORES
QUINTEROS Daniela Alejandra
artículos
Título:
“Equilibrium and Release Properties of Aqueous Dispersions of non Steroidal Antiinflammatory Drugs Complexed With Polyelectrolyte Eudragit E 100"
Autor/es:
DANIELA A QUINTEROS; DANIE A. ALLEMANDI; RUBEN H MANZO
Revista:
Scientia Pharmaceutica
Editorial:
Board
Referencias:
Año: 2012 p. 487 - 487
ISSN:
2218-0532
Resumen:
Abstract Equilibria and release properties of aqueous systems consisting of a set of five non steroidal antiinflammatory drugs (AH) complexed with the cationic polymethacrylate Eudragit E 100 (EU) are reported. The composition (EU(AH)50 (HCl)50) having fifty mole percent of each counterion (A- and Cl-) produces clear stable aqueous dispersions in which a remarcable high proportion of AH (higher than 98%) is condensed with the PE under the form of ion pairs. This property expands the interval of pH in which AH are aqueous soluble. The set of AH contains members with and without an alpha methyl group (-(CH3)CH-COOH: Flurbiprofen, Naproxen, Ketoprofen) and (-CH2-COOH: Diclofenac, Indomethacin). The proportion of ion pairs in the complexes was lower in the former group. Release of AH from the complexes towards a saline (NaCl 0.9%) solution was assayed in Franz cells. The five complexes behave as drug carriers that exhibited a slow drug release with a remarkable zero order. In line with the percentages of counterionic condensation observed, release rates from -(CH3)CH-COOH complexes were clearly higher than those of -CH2-COOH ones
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