INVESTIGADORES
BRUN Lucas Ricardo Martin
congresos y reuniones científicas
Título:
Hand bone mineral density in rheumatoid arthritis
Autor/es:
BRANCE ML; RAZZINI A; PONS-ESTEL BA; QUAGLIATO NJ; JORFEN M; BERBOTTO G; BRUN LR
Lugar:
Miami
Reunión:
Congreso; Congreso Panamericano de Reumatología 2020; 2020
Institución organizadora:
PANLAR
Resumen:
Introduction: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by symmetric polyarthritis that can lead to joint deformity and disability and also local and progressively and generalized osteoporosis. The gold standard diagnostic method for bone mineral density (BMD) is dual energy x-ray absorptiometry (DXA) of lumbar spine (LS) and femoral neck. Taking into account the hand are usually affected in RA, it was hypothesized that the evaluation of hand BMD could be useful in patients with RA. Objective: to evaluate the hands BMD in RA patients and compare with lumbar spine BMD. Patients and methods: Adult female and male RA patients (n=58) and control subjects (CG, n=33) matched by age, sex and body mass index (BMI) were included. BMD (g/cm2) was measured DXA (Hologic Discovery Wi) on LS and bilateral hands. Hands were evaluated through total hand BMD and in three regions of interest (carpus, metacarpus and phalanges). Intra-assay and inter-assay coefficient of variation (CV) of hand BMD were calculated. The distribution of the data was evaluated with the Shapiro-Wilk test and the differences between groups were analyzed using the Student's t test or the Mann-Whitney test, as appropriate. Pearson or Spearman correlation test were used for correlations. Data were expressed as mean±SD and p