CONICET | Buscador de Institutos y Recursos Humanos

The consumption of Yerba Mate (YM) is very common in South America. There is apopular belief that its consumption causes heartburn, gastric irritation orgastritis. However, there are poor scientific evidence and the information iscontradictory. The gastric mucosa is exposed to harmful substances and, if itsprotection mechanisms are exceeded, a gastric injury occurs. Gastritis is aninflammatory disease that involves multiple factors such Helicobacter pylori infection, NSAIDs, alcohol and tobacco use,genetic predisposition, etc. The damage of the mucosa depends on the time of injuryexposure, the intensity of it and the previous state of the gastric tissue. Theaim of this work was to evaluate the effect of different YM concentration ongastric mucosa without concomitant injurious. For this, 30-day Sprague Dawleyrats were divided into 3 groups (n=9/group) and they were given ad libitum: A. water, B. YM infusion (25g/500 ml, prepared at 70°C),C.YM concentrated infusion (50 g/500 ml, preparedat 90°C). After 90 days, the animals were sacrificed, the stomachs were excisedand digital images were taken for macroscopic assessment. For microscopicexamination, samples were taken from different zones, paraffin embedded andstained with H&E, in order to determine parameters of injury such as congestion,edema, hemorrhage, leucocyte infiltration, etc. Results: No macroscopic andmicroscopic mucosa differences between groups were found.The gastric mucosa showed preserved morphology in the four layers and without significantsigns of injury, both in control and treated animals (only few animals of all groupsshowed mild mucosal edema, congestion and discrete chronic inflammatoryinfiltrate). We can conclude that YM infusions would not produce deleteriouschanges in gastric mucosa. The effect of YM on damage mucosa or in the presenceof concomitant injurious factors should be assess for a completed evaluation.

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