Serum 25-hydroxyvitamin D levels in hospitalized adults with community-acquired pneumonia

BRANCE ML; MILJEVIC J; TIZZIANI R; TABERNA ME; GROSSI GP; TONI P; VALENTINI E; TREPAT A; ZACCARDI J; MORO J; FINUCI CURI B; TAMAGNONE N; RAMIREZ M; SEVERINI J; CHIAROTTI P; CONSIGLIO F; PIÑESKY R; GHELFI A; KILSTEIN J; STREET E; MORETTI D; OLIVETO V; MARIÑO M; MANERA J; BRUN LR

Denver

Congreso; American Society for Bone and Mineral Research Meeting 2017; 2017

American Society for Bone and Mineral Research

Several studies have shown an association betweenvitamin D deficiency and increases susceptibility to respiratory tractinfections. The aim of this study was to evaluate the serum 25-hydroxyvitamin D(25OHD) levels in hospitalized adults with community-acquired pneumonia (CAP)in Rosario city, Argentina. Materials and methods: An observational study with207 hospitalized adults of both sex with CAP over 18 years from Rosario city(32º52'18''S) were carried out from July 2015 to June 2016. Exclusion criteria:CAP that was not the primary cause of hospitalization, patients hospitalized inthe last 14 days, or who had oncological antecedents, AIDS, chronic renal orliver disease, autoimmune or connective diseases, or were treated withglucocorticoids, anticonvulsants or vitamin D. Theresults are expressed as mean±EE. Data distribution was analyzed using theKolmogorov-Smirnov test and the comparison between groups was performed withparametric and non-parametric tests as appropriate. Results: 207 patients withCAP were recruited, and 167 were included in this study (59% women, 57.4±1.5 years, body mass index 27.1±0.8 kg/m2 and 6.6±0.4 days of hospitalization). The most common clinicalmanifestations were: 81.8% fever, 77.1% cough with expectoration, 75.8% dysneaand 40.2% chest pain. In the radiography, 62.5% showed unilobar infiltrate and in37.5% were multilobar. Unilateral pleural effusion was found in 10.6% and only4% was bilateral. The CURB65 index was 66.7% low risk, 16.0% intermediate riskand 17.3% high risk. According to Charlson comorbidity index (CCI) 53.5% hadnot comorbidity (CCI=0) and 46.5% showed CCI≥1. The 25OHD level (ng/ml) was: 11.92±0.58 (51.5%: <10 ng/ml, 33.5%: 10-20 ng/ml, 13.2%:20-30 ng/ml, 1.8%: >30 ng/ml). 25OHD correlated with age (r= -0.17; p=0.02)and higher 25OHD were found in male (female: 10.83±0.67, male: 13.51±1.03, p=0.02). Due to the characteristics of thepathology under study, 54% were in winter, 28% spring, 2% summer and 15%autumn. 25OHD in winter-spring (11.05±0.55) were lower than summer-autumn (16.12±2.04, p=0.01). 25OHD correlated with CURB65 score (r=-0.13; p=0.049), CCI (r= -0.20, p=0.007) and with the 10 years life expectative(%) calculated with age and CCI (r= 0.19; p=0.008). In addittion, higher 25OHDwere found with lower CCI (0= 13.04±0.89, ³1= 10.50±0.79, p=0.009). It is concluded that hospitalizedadults with CAP have lower 25OHD levels and would be associated with CAPseverity.