INVESTIGADORES
BRUN Lucas Ricardo Martin
artículos
Título:
Serum 25-hydroxyvitamin D levels in hospitalized adults with community-acquired pneumonia
Autor/es:
BRANCE ML; MILJEVIC, JULIO N.; TIZZIANI, RAQUEL; TABERNA, MARÍA E.; GROSSI, GEORGINA P.; TONI, PABLO; VALENTINI, ELINA; TREPAT, ANDREA; ZACCARDI, JULIA; MORO, JUAN; FINUCI CURI, BALTASAR; TAMAGNONE, NORBERTO; RAMIREZ, MARIANO; SEVERINI, JAVIER; CHIAROTTI, PABLO; CONSIGLIO, FRANCISCO; PIÑESKI, RAÚL; GHELFI, ALBERTINA; KILSTEIN, JORGE; STREET, EDUARDO; MORETTI, DINO; OLIVETO, VIVIANA; MARIÑO, MARCELO; MANERA, JORGE; BRUN LR
Revista:
CLINICAL RESPIRATORY JOURNAL
Editorial:
WILEY-BLACKWELL PUBLISHING, INC
Referencias:
Año: 2018 vol. 12 p. 2220 - 2227
ISSN:
1752-6981
Resumen:
Introduction: Community-acquiredpneumonia (CAP) is the infectious disease with the highest number of deathsworldwide. Several studies have shown an association between vitamin Ddeficiency and increases susceptibility to respiratory tract infections. Objective:The aim of this study was to evaluate the serum 25-hydroxyvitamin D (25OHD)levels in hospitalized adults in general room with CAP. Materials and methods:An observational study was carried out in 207 hospitalized adults of both sexwith CAP over 18 years from Rosario city, Argentina (32º 52´ 18´´S) betweenJuly 2015 to June 2016. Results: 167 patients were included in the dataanalysis (59% women, 57.4±19.6 years, bodymass index 27.2±7.8 kg/m2). The 63% showed unilobar infiltrate andin 37% were multilobar. The CURB-65 index was 66.5% low risk, 16.0%intermediate risk and 17.5% high risk. According to Charlson comorbidity index(CCI) 53.5% had not comorbidity (CCI=0) and 46.5% showed CCI≥1. The 25OHD levelwas: 11.92±7.6 ng/ml(51.5%: <10 ng/ml, 33.5%: 10-20 ng/ml, 13.2%: 20-30 ng/ml, 1.8%: >30ng/ml). Higher 25OHD were found in male (female: 10.8±6.7 ng/ml, male: 13.5±8.5 ng/ml, p=0.02) and 25OHD correlated with age (r=-0.17; p=0.02). 25OHD also correlated with CURB65 index (r= -0.13; p=0.049),CCI (r= -0.20, p=0.007) and with the 10 years life expectative (%) (r= 0.19;p=0.008). In addition, higher 25OHD were found with lower CCI (CCI 0= 13.0±8.2ng/ml, CCI ³1= 10.5±6.7ng/ml; p=0.0093). Conclusion: hospitalized adults with CAP have lower 25OHDlevels and would be associated with CAP severity.