INVESTIGADORES
BRUN Lucas Ricardo Martin
artículos
Título:
Fluoride inhibits in vitro and in vivo oxygen consumption and induces oxidative stress
Autor/es:
FINA BL; BRANCE ML; BRUN LR; RIGALLI A
Revista:
FLUORIDE
Editorial:
INT SOC FLUORIDE RESEARCH
Referencias:
Año: 2012 vol. 45 p. 325 - 330
ISSN:
0015-4725
Resumen:
Fluoride (F) increases reactive oxygen species (ROS) probably by a modification in the respiratory chain. The aim of this work was to evaluate the effect of F on oxygen consumption (VO2) in rats. Eighteen Sprague-Dawley rats were divided in groups: Control, NaF20 and NaF40, which received 0, 20 and 40 µmolF/100g bw.day for 30 days, respectively. In vivo, VO2 decreased 90 min after F dose. TBARS, CAT and GPx were higher in NaF-treated groups. In vitro, F decreased VO2 in liver and in mitochondria. These results support the hypothesis that the inflammatory foci observed in treatments with NaF could be due to an inhibition of the respiratory chain which would cause increase in ROS.
