INVESTIGADORES
MOLLERACH Marta Eugenia
artículos
Título:
Phenotypic and genotypic characterization of macrolide resistant Streptococcus pneumoniae recovered from adult patients with community-acquired pneumonia in Argentinian Teaching Hospital.
Autor/es:
BONOFIGLIO L; OJEDA MI; DE MIER C; VAY C; FAMIGLIETTI A; GUTKIND G; MOLLERACH M
Revista:
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
Editorial:
Elsevier B.V.
Referencias:
Año: 2005 vol. 25 p. 260 - 263
ISSN:
0924-8579
Resumen:
Streptococcus pneumoniae isolates (n = 262) were recovered from adult patients with community-acquired pneumonia. Erythromycinresistance levels increased from 9% (1997–1998) to 16% (2000–2002). Sampling for resistance mechanisms prevalent within 19 erythromycinresistant S. pneumoniae showed mef(E) in 13/19 isolates while 4/19 carried the erm(B) gene (3/19 cMLSB and 1/19 iMLSB phenotype). MIC ranges for erythromycin and clindamycin were 0.5–16 mg/l and <0.008–0.063 mg/l for theMphenotype, 128–512 mg/l and 128–256 mg/l for the cMLSB phenotype, and 4 and <0.008 mg/l for the iMLSB phenotype. This is the first report studying the prevalence of macrolide resistance determinants in S. pneumoniae in our country.