Development and Evaluation of Magnetite Loaded Alginate Beads Based Nanocomposite for Enhanced Targeted Analgesic Drug Delivery

AMRITA DAS; PRATEEP SENGUPTA; SHREYA CHATTERJEE; JASMINA KHANAM; PRANAB KUMAR MONDAL; EDER LILIA ROMERO; ANTON M. MANAKHOV; SABU THOMAS; SYED MAHMOOD; KAJAL GHOSAL

MAGNETOCHEMISTRY

MOLECULAR DIVERSITY PRESERVATION INTERNATIONAL-MDPI

Año: 2025

2312-7481

Iron oxide-based nanoparticles, such as magnetic nanoparticles (MNPs), havegained significant attention in the area of drug delivery due to their unique magnetic properties, allowing for precise targeting and controlled release of therapeutic agents. Severalsuccessful research studies were reported with combinations of magnetic nanoparticles andpolysaccharides such as sodium alginate, chitosan, cellulose, etc. The presented researchwork is based on synthesising MNPs via the co-precipitation method and their successfulencapsulation within alginate beads, serving as a promising drug delivery system foraceclofenac, a model drug. The physical and chemical characteristics of both the preparedmagnetite nanoparticles and the aceclofenac-loaded MNPs alginate beads were thoroughlyexamined using scanning electron microscopy (SEM), high-resolution transmission electron microscopy (HRTEM), Fourier-transform infrared spectroscopy (FTIR), powder X-raydiffraction (PXRD), and vibrating sample magnetometry (VSM). Furthermore, a drug release study was conducted to evaluate the release kinetics of aceclofenac from the preparedMNP alginate beads. The magnetic characteristics of magnetite and MNP beads shed lighton the potential application of novel drug delivery systems for magnetically targeted therapeutic interventions. The present research offers valuable insights into the developmentof magnetic nanoparticle-based drug carriers, paving the way for enhanced drug deliverystrategies in the field of pharmaceutical sciences.