INVESTIGADORES
WUNDERLIN Daniel Alberto
artículos
Título:
Green Synthesis of Potential Antifungal Agents: 2-Benzyl Substituted Thiobenzoazoles
Autor/es:
BALLARI, MARÍA SOL; HERRERA CANO, NATIVIDAD; LOPEZ, ABEL GERARDO; WUNDERLIN, DANIEL ALBERTO; FERESÍN, GABRIELA EGLY; SANTIAGO, ANA NOEMÍ
Revista:
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Editorial:
AMER CHEMICAL SOC
Referencias:
Año: 2017 vol. 65 p. 10325 - 10331
ISSN:
0021-8561
Resumen:
A series of benzyl-substituted thiobenzoazoles were synthesized by an environmentally friendly approach, to search for new antifungal agrochemicals. Compounds were prepared starting from 2-mercaptobenzoazoles, using KOH, benzyl halides, and water, resulting in a simple and ecological method. New antifungals were tested against a group of phytopathogenic fungi. Two compounds showed an interesting activity against Botrytis cinerea, Fusarium oxysporum, and Aspergillus spp.: 2-((4-(trifluoromethyl)benzyl)thio)benzo[d]thiazole, 3ac, and 2-((4-methylbenzyl)thio)benzo[d]thiazole, 3al. Thus, 3ac and 3al can be considered as broad spectrum antifungal agents. Furthermore, two new compounds, 2-((4-iodobenzyl)thio)benzo[d]thiazole, 3aj, and 2-(benzylthio)benzo[d]oxazole, 3ba, showed better inhibitory effect against Botrytis cinerea and Fusarium oxysporum when compared to the commercial fungicide Captan. Thus, 3aj and 3ba can be considered reduced-spectrum antifungals.