A simple hydride generation CE-ICP-MS interface for arsenic speciation

RICHARDSON, DOUGLAS D.; WUILLOUD, RODOLFO G.; KANNAMKUMARATH, SASI S.; CARUSO, JOSEPH A.

Fort Lauderdale, Florida

Conferencia; 2004 WINTER CONFERENCE ON PLASMA SPECTROCHEMISTRY; 2004

2004 WINTER CONFERENCE ON PLASMA SPECTROCHEMISTRY

Capillary electrophoresis (CE) coupled with inductively coupled plasma mass spectrometry (ICP-MS) has become a popular technique for the separation, identification, and quantitation in elemental speciation. One common drawback from this technique is the poor sample introduction efficiency of the CE-ICP-MS interface that limits the sensitivity by ICP-MS detection.1 Hydride generation (HG) coupled to ICP-MS has been reported to improve detection limits. The formation of volatile hydrides results in a more efficient element transportation to the plasma and better sample ionization. Previous research has shown that CE-HG-ICP-MS is a reliable technique for the speciation of hydride forming elements.2 However, the detection limits were not as low as those obtained with the conventional HG-ICP-MS technique.1 In this work an alternative CE-HG-ICP-MS interface for arsenic speciation is described. This interface consisted of a conventional nebulization system as a gas-liquid separator for HG system. Optimization of the variables involved in the HG system was performed to obtain low dispersion of the transient signals generated by the CE device. Analytical figures of merit with the proposed interface were determined and compared with those obtained by CE-ICP-MS.        1. Sasi S. Kannamkumarath, Katarzyna Wrobel, Kazimierz Wrobel, Clayton B'Hymer, Joseph A. Caruso, "Capillary Electrophoresis - Inductively coupled plasma-mass spectrometry: an attractive complementary technique for elemental speciation analysis" Journal of chromatography A, 2002, 975, 245-266.2. Magnuson M L; Creed J T; Brockhoff C A  Speciation of selenium and arsenic compounds by capillary electrophoresis with hydrodynamically modified electroosmotic flow and on-line reduction of selenium(VI) to selenium(IV) with hydride generation inductively coupled plasma mass spectrometric detection. ANALYST (1997 Oct),  122(10),  1057-61.