Impact of two breast-milk derived potential probiotics on the gut microbiota of an obese child.

ODDI, SOFIA; HUBER, M.; REINEHIMER, J.; BURNS, P.; VINDEROLA CG; SIVIERI, K.

Simposio; 8th Gut Microbiota For Health Summit; 2019

The gut microbiota is emerging as a new factor in the development of metabolic diseases such as obesity and type 2 diabetes because of unhealthy eating behavior, sedentary lifestyle and environmental conditions. In this sense, prevention and management of obesity are proposed to begin in childhood and the role of prebiotics and probiotics has been studied with promising results by the modulation of gut bacteria and their metabolites such Short-Chain Fatty Acids (SCFAs) and ammonium ions (Sanchez M., Panahi S.  Tremblay A., 2014).Dynamic in vitro systems, as for example the Simulator of the Human Intestinal Microbial Ecosystem (SHIME®), are useful tools to study novel probiotics. The SHIME® is a validated in vitro system able to simulate the different parts of the gastrointestinal tract, proven to be very useful in analyzing the human intestinal microbial community (Bianchi et al. 2018).