INVESTIGADORES
VINDEROLA Celso Gabriel
artículos
Título:
Administration of caseinomacropeptide-enriched extract to mice enhances the calcium content of femur in a low-calcium diet
Autor/es:
BURNS P; TORTI, P.; BINETTI A; FORZANI, L.; RENZULLI, P.; VINDEROLA C.G.
Revista:
INTERNATIONAL DAIRY JOURNAL
Editorial:
ELSEVIER SCI LTD
Referencias:
Lugar: Amsterdam; Año: 2015 vol. 44 p. 15 - 20
ISSN:
0958-6946
Resumen:
Caseinomacropeptide (CMP) is the 64 C-terminal amino acid residue of k-casein, formed by chymosin
cleavage during cheese manufacture. This study examined the effects of oral administration of a CMPenriched
extract (CMPEE), obtained from a local dairy plant, on the Ca content of mouse femurs. Animals
received low (0.1%, w/v), normal (0.5%, w/v) or high (1.2%, w/v) Ca diet for 3 or 8 weeks and CMPEE
diluted (1:10) in their drinking water. No significant differences in Ca content were observed in faeces,
kidney, urine or blood serum compared with control animals. The oral administration of CMP to mice
significantly enhanced the Ca content in femur under a low-Ca diet model, especially during the period of
full body development (3 weeks), in which case a significant 12% Ca increase was observed. These
findings pave the way for further studies aimed at supplementing infant food with industrially-obtained
CMP-enriched extract for enhanced bone health.