INVESTIGADORES
VATTA Marcelo Sergio
artículos
Título:
Atrial natriuretic factor modifies noradrenaline release in a sodium-free medium
Autor/es:
VATTA MS; PAPOUCHADO ML; LOCATELLI AS; BIANCIOTTI LG; FERNADEZ BE
Revista:
JOURNAL OF AUTONOMIC PHARMACOLOGY
Editorial:
John Wiley & Sons Ltd
Referencias:
Año: 1994 vol. 14 p. 267 - 273
ISSN:
0144-1795
Resumen:
1 The effects of atrial natriuretic factor (ANF) on 3H-noradrenaline (3H-NA) release
evoked by a sodium-free medium (SFM) were studied. The experiments were carried
out in rat hypothalamic slices incubated in vifro.
2 ANF (1, 10 and 100 nM) decreased NA release evoked by the omission of sodium
in a concentration-dependent way. When calcium was omitted from a SFM, NA
output was partially diminished. However, if ANF was added to the SFM/calcium
free medium NA secretion showed no modifications.
3 Present results suggest that, in rat hypothalamus, NA release evoked by Na'
omission is divided into two fractions: one independent of and the other dependent
on extracellular calcium. In addition, ANF modifies NA release evoked by SFM
dependent on extracellular calcium.
