INVESTIGADORES
VATTA Marcelo Sergio
artículos
Título:
Atrial natriuretic factor enhances induced salivary secretion in the rat
Autor/es:
BIANCIOTTI LG; ELVERDIN J; VATTA MS; COLATRELLA C; FERNADEZ BE
Revista:
REGULATORY PEPTIDES
Editorial:
ELSEVIER SCIENCE BV
Referencias:
Lugar: Amsterdam; Año: 1994 vol. 49 p. 195 - 202
ISSN:
0167-0115
Resumen:
As atrial natriuretic factor (ANF) is intimately involved in water and electrolyte homeostasis, dose-response
studies were performed in the parotid as well as submaxillary glands of the rat with increasing doses of the atrial
peptide to investigate its possible role as a sialogogic agent. Dose-response studies were also performed in both
salivary glands with different pharmacological agonists known to cause salivation in the rat (methacholine,
noradrenaline, isoproterenol, methoxamine and substance P) in the absence and in the presence of ANF. The
atrial factor did not induce salivation 'per se' at least in the investigated doses. However, it enhanced the salivary
response to methacholine, methoxamine and substance P but it did not modify the salivation induced either
by noradrenaline or isoproterenol. The present results showed that ANF enhanced the salivation induced by
pharmacological agents which stimulate phosphatidylinositol hydrolysis. These effects of ANF may be probably
related to the activation of the non-guanylate cyclase coupled receptor which has been associated with
phosphatidylinositol turnover. Nevertheless, although the atrial factor induces vasorelaxation, its enhancement
of blood flow may not be the major event underlying the present results. The present work suggests a potential
physiological role of ANF on the modulation of salivary secretion and provides further evidence on the rol
of ANF in the regulation of body fluid homeostasis.