INVESTIGADORES
VATTA Marcelo Sergio
artículos
Título:
Atria1 Natriuretic Factor Increases Peritoneal Dialys:is Efficiency in Nephrectomized Rats
Autor/es:
BIANCIOTTI LG; VATTA MS; BENGOCHEA L; PUYO AM; FERNADEZ BE
Revista:
PEPTIDES
Editorial:
ELSEVIER SCIENCE INC
Referencias:
Lugar: Amsterdam; Año: 1996 vol. 17 p. 87 - 92
ISSN:
0196-9781
Resumen:
effect of atria1 natriureticfactor (ANF) on peritoneal dialysis was studied in bilaterally nephrectomized rats. ANF was injected prior to every dialysisexchange and blood samples were obtained before the instillation of the dialysis solution and during the collection of dialysates.Urea, creatinine, potassium, and sodium were determined in both plasma and dialysates. Results showed that ANF increased theplasma clearance of all studied solutes, probably through vasodilation. Solute clearances showed a gradual increase with eachdialysis exchange in both control and experimental animals. Therefore, ANF plasma levels were assayed before, during, and afterperitoneal dialysis in a control group of nephrectomized rats to determine whether ANF plasma levels were modified duringdialysis. Plasma ANF values were higher during and after peritoneal dialysis, though basal levels were similar to those of nonnephrectomizedrats. These results suggest the release of endogenous ANF from the cardiac atria during peritoneal dialysis. Thepresent results suggest that ANF may be of potential interest in the clinical field to increase the efficiency of peritoneal dialysisin man.