Atrial natriuretic factor modifies the composition of induced-salivary secretion in the rat

BIANCIOTTI LG; ELVERDIN J; VATTA MS; FERNADEZ BE

REGULATORY PEPTIDES

ELSEVIER SCIENCE BV

Lugar: Amsterdam; Año: 1996 vol. 65 p. 139 - 143

0167-0115

We have previously repotled that although the atrial natriuretic factor (ANF) was not a sialogogic agonist, it enhanced cholinergic,a-adrenergic and peptidergic (substance P) stimulated salivation in the submaxillary and parotid gland of the rat. The purpose of thepresent work was to study whether ANF modified the composition of agonist-induced saliva in the rat. Results showed that in thesubmaxillary gland, ANF increased sodium and decreased potassium excretion when salivation was stimulated by methacholine (MC) orsubstance P (SP). However, when salivation was induced by methoxamine (MX), ANF only increased sodium excretion. On the otherhand, in the parotid gland, ANF increased both sodium and potassium excretion when salivation was induced either by MC or SP but didnot modify electrolyte output in MX induced salivary secretion. Protein output and amylase activity were not modified by the presence ofANF when the aforementioned sialogogic agonists were used to elicit salivation in either gland. Although ANF did not modify thevolume of isoproterenol (IP) induced saliva, it increased protein output in both glands and it increased amylase activity in the parotidgland. The present results suggest that ANF may play a role in the modulation of salivary secretion in the parotid and submaxillary glandsof the rat. ANF effect is likely to be mediated by modifications in the calcium level linked to phosphoinositide metabolism within theacinar and/or the ductal cell~ of the salivary glands.