INVESTIGADORES
VATTA Marcelo Sergio
artículos
Título:
NPR-C receptors are involved in C-type natriuretic peptide response on bile secretion
Autor/es:
SABBATINI M; VATTA MS; VESCINA C; GONZALES S; FERNADEZ BE; BIANCIOTTI LG
Revista:
REGULATORY PEPTIDES
Editorial:
ELSEVIER SCIENCE BV
Referencias:
Lugar: Amsterdam; Año: 2003 vol. 116 p. 13 - 20
ISSN:
0167-0115
Resumen:
C-type natriuretic peptide (CNP) is a member of the natriuretic peptide family. Previous studies reported the presence of natriureticpeptide receptors and mRNA CNP in the liver. In the present work, we sought to establish the role of CNP in the regulation of bile secretionin the rat and the possible pathways involved.CNP diminished basal as well as bile salt-evoked bile flow and bile acid output in a dose-dependent manner. It also reduced the excretionof sodium, chloride, and potassium but did not modify bile pH or the excretion of phospholipids, total proteins, and glutathione. Neitherparasympathetic nor sympathetic blockade abolished CNP inhibitory response on bile secretion. The selective NPR-C agonist, C-ANP-(4-23)amide, diminished bile flow and the co-administration of both peptides did not further decrease it. CNP did not alter mean arterial pressure orportal venous pressure at any given doses.CNP decreased bile acid-dependent flow without affecting bile acid-independent flow. The inhibitory effect of CNP did not involve theparticipation of the autonomic nervous system or hemodynamic changes. The participation of NPR-C receptors in CNP response is stronglysupported by present findings. The present study shows that CNP modulates bile secretion in the rat, suggesting that CNP may be part of thelarge family of peptides involved in the regulation of gastrointestinal physiology