Endothelin-3 applied to the brain evokes opposite effects on bile secretion mediated by a central nitric oxide pathway

MYRIAN R. RODRIGUEZ; MARIA E. SABBATINI; GISELA SANTELLA; PAULA DABAS; ALBERTO VILLAGRA; MARCELO S. VATTA; LILIANA G. BIANCIOTTI

PEPTIDES

Elsevier

Lugar: Amsterdam; Año: 2005 vol. 25 p. 1219 - 1227

0196-9781

We sought to establish Endothelin (ET-3) role in the central regulation of bile secretion in the rat. The intracerebroventricular (icv) injection of ET-3 evoked a cholestatic or a choleretic effect depending on the administered dose. Lower doses increased bile flow and bicarbonate excretion, whereas higher doses decreased bile flow and bile acid output. ET-3 effects were dependent on brain nitric oxide and independent of the autonomic nervous system or hemodynamic variations. A selective ETB antagonist abolished the cholestatic effect, whereas the choleretic effect was totally inhibited by either ETA or ETB selective blockade. These results show that ET-3 applied to the brain modified through a nitric oxide pathway distinct bile flow fractions depending on the administered dose and give further insights into the complexity of brain–liver interaction.B antagonist abolished the cholestatic effect, whereas the choleretic effect was totally inhibited by either ETA or ETB selective blockade. These results show that ET-3 applied to the brain modified through a nitric oxide pathway distinct bile flow fractions depending on the administered dose and give further insights into the complexity of brain–liver interaction.