Levoglucosenone and its derivatives: new alternatives for breast cancer treatment

ALDANA SCHEY; LIZETH ARIZA BAREÑO; LUCIANA CAÑONERO; ANDRES BECHIS; DIEGO BRITEZ NEIRA; FLORENCIA CÁMPORA; BEATRIZ E. PAVA GÓMEZ; ARIEL M. SAROTTI; ALEJANDRA SUAREZ; ROLANDO SPANEVELLO; MARCELA SOLANGE VILLAVERDE; LAURA B. TODARO; ALEJANDRO J. URTREGER

Mar del Plata

Congreso; LXVII Reunión Científica de la Sociedad Argentina de Investigación Clínica (SAIC); 2022

Sociedad Argentina de Investigación Clínica (SAIC)

Breast cancer is a major public health problem, being the second leading cause of cancer death among women in developed countries. Levoglucosenone results from pyrolytic treatment of cellulose-containing materials, and it has been used for the synthesis of different biological compounds but its usefulness in oncology remains unexplored. In vitro, levoglucosenone (compound 1) and structurally related derivatives (compounds 2, 3 and 4) showed a strong antiproliferative effect associated with apoptosis induction. In vivo compounds 1 and 2 highly reduced tumor growth and lung dissemination.In this work we determined the effect of combining the compounds with cell metabolism modulators and evaluated the effect of new derivatives.Using the fluorophore TMRM we observed that the compounds induce the loss of mitochondrial membrane potential which could the responsible of the apoptosis induction. Moreover, as an energetic compensatory process, a 2-fold increase of glucose consumption and lactate production was detected (p