INVESTIGADORES
SOMOZA Gustavo Manuel
congresos y reuniones científicas
Título:
Detection of alternative splicing events in the kisspeptin receptors in pejerrey (Odontesthes bonariensis).
Autor/es:
ALEJANDRO S. MECHALY; OSWALDO TOVAR; DANIELA CAMPANELLA; LUIS F. CANOSA; GUILLERMO ORTÍ; GUSTAVO M. SOMOZA
Lugar:
Chascomus
Reunión:
Congreso; XVI Jornadas Anuales de la Sociedad Argentina de Biología; 2014
Institución organizadora:
Sociedad Argentina de Biología
Resumen:
In mammals, the kisspeptin system is composed by the kisspeptin neuropeptide ligand and its receptor, KISSR. This system is primarily involved in the neuroendocrine regulation of puberty and sexual maturation. Recent studies have demonstrated the existence of a teleost-specific whole genomic duplication. Then, several fish species presented two kissr genes (Kiss1rb and Kiss2rb). In this study, we report the presence of two kisspeptin receptors in the pejerrey, Odontesthes bonariensis: pjKiss1rb and pjKiss2rb. The genomic structure of pjKiss1rb comprises seven exons and six introns. On the other hand pjKiss2b comprises five exons and four introns. In the case of pjKiss2rb, two distinct transcripts were detected having a difference of 100 bp in length. The longer transcript contained an insert of 98 nucleotides caused by the retention of third intron. The sequence of this transcript has two premature stop codons. Future studies will aim to understand the importance of alternative transcription in the regulation of kisspeptin receptor expression.
