INVESTIGADORES
SOMOZA Gustavo Manuel
artículos
Título:
GnRH molecular variants in the brain and pituitary gland of pejerrey, Odontesthes bonariensis (Atheriniformes). Chromatographic and immunological evidence for the presence of a novel molecular variant.
Autor/es:
ANDREA STEFANO; LUIS F CANOSA; JOSE L D ERAMO; OSVALDO FRIDMAN; JORGE AFFANNI; GUSTAVO M SOMOZA; GUSTAVO M SOMOZA
Revista:
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY. C, COMPARATIVE PHARMACOLOGY AND TOXICOLOGY.
Editorial:
Elsevier
Referencias:
Año: 1997 vol. 118 p. 335 - 345
ISSN:
0742-8413
Resumen:
Gonadotropin releasing hormone (GnRH) molecular variants in the brain and pituitary gland of pejerrey Odontesthes bonariensis (Atheriniformes) were characterized by reverse phase high performance liquid chromatography (RP-HPLC). Eluted fractions were tested in radioimmunoassays with different antisera. The results show that the brain extract contains three forms of GnRH: one is immunological and  chromatographically similar to cIIGnRH (chicken II), and another is similar to sGnRH (salmon). A third GnRH apperas to be chromatographically and immunologically different from the nine other forms of the vertebrate hormone. This is the only variant present in the pituitary gland.