Molecular pathways involved in the regulation of pituitary tumor oncogenesis and senescence

SAPOCHNIK, MELANIE; ROSMINO, JOSEFINA; STALLA, GK ; HERBSTEIN, FLORENCIA; SENIN, SERGIO; ARZT, EDUARDO; FUERTES, MARIANA; NIETO, LEANDRO E.; ATTORRESI, ALEJANDRA

Ciudad Autónoma de Buenos Aires

Congreso; Frontiers in Bioscience 3; 2018

IBioBA - MPSP - CONICET

Pituitary tumors derive from normal endocrine cells orprecursors of them and form endocrine active or inactiveadenomas. Despite considerable progress, thepathogenesis of pituitary adenomas is still not clear.Pituitary tumors are of monoclonal origin which meansthat they derive from a single transformed cell. Mutation inoncogenes and/or tumor suppressors are expected toinitiate this process. Increased levels of the protooncogenePituitary tumor transforming gene (PTTG)have been repeatedly reported with a critical role inpituitary tumorigenesis, however no mutations,epigenetic modifications or other mechanisms thatderegulate its expression have not been found.Despite their high abundance, very rarely these tumorsprogress to a malignant stage. Senescence has beenproposed as one of the mechanisms underlying thisbenign behavior, although the mechanism is still unknown.We propose that IL-6 which is produced by the tumoralcells participates in an autocrine senesce loop.