Biological models for search of genes involved in cencerogenesis

ARZT, E.

La Plata

Workshop; Biointerfaces: Cell - Material Interactions; 2015

INIFTA-CONICET-UNLP

The workshop will focus on challenging aspects of the interaction of living cells with extracellulary presented molecules - molecules being either in soluble form, immobilized at interfaces, presented in nanoscale clusters, or immobilized to the extracellular matrix (ECM) - with the aim to understand how these interactions regulate the funcionality and fate of cells.This task is extremely challenging given the complex molecular arsenal involved in cellular sensing and the processing of external stimuli, which encompasses a wide range of physical and chemical cues that are generated at, or act on, the adhesive interface. This requires scientific breakthroughs on the level of presenting molecules to the membrane of cells, measuring cellular consequences spatially and temporarily resolved and to handle such big and complex sets of data. Engineering of biomimetic nanoscale systems for the controlled manipulation and analysis of cells in vitro and in vivo has become important aspects of competitive research groups worldwide, particularly in biophysics, biomaterials and biomedical applications.Biologically inspired materials that mimic the cell's natural surrounding with nanometric resolution and have the ability to transduce cellular signaling activities are ideal candidates for gaining insights into the chemical and physical signals regulating cellular events. To achieve substantial progress in this area, a combination of expertise ranging from synthetic chemistry and material science to physical characterization and bioengineering proves to be a good scientific combination for these goals.