IBIOBA - MPSP 22718
INSTITUTO DE INVESTIGACION EN BIOMEDICINA DE BUENOS AIRES - INSTITUTO PARTNER DE LA SOCIEDAD MAX PLANCK
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Rol of TGFbeta/SMAD family proteins mediated transcriptional regulation of genes involved in pluripotency and tumorigenicity in embryonic and cancer stem cells
Autor/es:
EVANGELINA GALIAN; RODRIGO GONZALO PARRA; CRISTIAN OSCAR ROHR; MASAYO YUMOTO; RIK DERYNCK; CAROLINA PEREZ CASTRO
Lugar:
Buenos Aires
Reunión:
Simposio; Frontiers in BioScience; 2012
Institución organizadora:
Biomedicine Research Institute of Buenos Aires CONICET - Partner Institute of the Max Planck Society
Resumen:
Embryonic stem cells (ESCs) are characterized by their ability of self-renew and to have pluripotency under certain culture conditions in vitro. Both in human and mouse ESCs, a group of conserved transcription factors called Core composed by Oct-4, Sox-2 and Nanog, is responsible of ESCs properties. Also, TGFbeta/Smad factors (TGFbeta/Activin, BMPs) are necessary to maintain/modulate pluripotency states. In addition, there are evidences suggesting the existence of additional factors required for ESCs properties. Our works aim to investigate the mechanisms involved in stem cell self-renewal and pluripotency. In particular, we are interested to study how proteins TGFbeta/Smad co-regulate the activity of target genes of the Core and how they influence on cell behavior.
