Glucocorticoids inhibit the expression of interleukin 17, key effector cytokine of T helper lineage 17

ANTUNICA NOGUEROL, M; APRILE GARCIA, F; CASTRO, CN; BARCALA TABARROZZI, AE; PERONE, MJ; LIBERMAN, AC; ARZT, E

Capital Federal

Workshop; Frontiers in BioScience” Joint Symposium of the Max Planck Society and the Ministry of Science, Technology and Innovation; 2012

Glucocorticoids (GCs) are the most potent and frequently used anti-inflammatory drugs for a variety of T helper (h) 1- and Th2-mediated inflammatory and immune disorders. Recently, interleukin (IL) 17 has been associated to the pathogenesis of autoimmune disorders. The major population producing this cytokine is a newly discovered lineage of Th cells, Th17and RORγt is the master transcripton factor (TF) involved in Th17 development and interleukin (IL)-17A production. Therefore, we aim to characterize the molecular mechanism underlying the effect of GCs on the production of this cytokine and the transcriptional activity of RORγt in order to identify novel therapeutic targets.