Study of the transcriptional network regulation by TGFbeta/Smad family proteins in embryonic stem cells.

C PEREZ CASTRO

Workshop; Workshop/Evaluación del comité asesor externo del PAE: -“Estudio transversal y multidisciplinario sobre utilización terapéutica de células madre modificadas genéticamente”. . Organizado por el Consorcio en Investigación de Células Madre (CICEMA).; 2011

To elucidate the molecular mechanisms underlying ES cells stemness and its relation to cell behavior we designed a novel bioinformatics algorithm to search for those genes (candidate genes) that might be under the regulation of the core transcriptional factors (Sox-2/Oct-4, Nanog) that confer stemness properties and the TGF-β/Smad pathway. At the same time, we also investigate possible correlation between these candidate genes with the ES response to hypoxia and other pathways that also control ES properties and cell behavior.