SUMO conjugation as regulator of the glucocorticoid receptor-FKBP51 cellular response to stress

BUDZIÑSKI, MAIA L.; UGO, MARIA B.; BUDZIÑSKI, MAIA L.; UGO, MARIA B.; LIBERMAN, ANA C.; GOBBINI, ROMINA P.; LIBERMAN, ANA C.; GOBBINI, ROMINA P.; SOKN, CLARA; ARZT, EDUARDO; SOKN, CLARA; ARZT, EDUARDO

STEROIDS

ELSEVIER SCIENCE INC

Año: 2019 vol. 153

0039-128X

n order to adequately respond to stressful stimuli, glucocorticoids (GCs) target almost every tissue of the body.By exerting a negative feedback loop in the hypothalamic?pituitary?adrenal (HPA) axis GCs inhibit their ownsynthesis and restore homeostasis. GCs actions are mostly mediated by the GC receptor (GR), a member of thenuclear receptor superfamily. Alterations of the GR activity have been associated to different diseases includingmood disorders and can lead to severe complication. Therefore, understanding the molecular complexity of GRmodulation is mandatory for the development of new and effective drugs for treating GR-associated disorders.FKBP51 is a GR chaperone that has gained much attention because it is a strong inhibitor of GR activity and has acrucial role in psychiatric diseases. Both GR and FKBP51 activity are regulated by SUMOylation, a post-translational (PTM). In this review, we focus on the impact of SUMO-conjugation as a regulator of this pathway